N,5-二乙基-4-羟基-1-甲基-2-氧代-N-苯基-1,2-二氢喹啉-3-甲酰胺; 化合物PAQUINIMOD; ABR-215757; ABR 25757; ABR-25757; ABR25757; N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
用途
- 生物活性
Paquinimod (ABR 25757) 是一种 S100A8/S100A9 的特异性抑制剂，通过降低 SARS-CoV-2 感染小鼠的病毒载量来用于肺炎的研究。
- 靶点
S100A9
- 体内研究
S100A9 is a calcium-binding protein of the S100 family. Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. Prophylactic treatment with S100A9 inhibitor Paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Paquinimod is a potent inhibitor of insulitis and diabetes development in the NOD mouse. To assess the preventive efficacy of Paquinimod on diabetes development in female NOD mice, groups of mice are treated with daily doses of 0.04, 0.2, 1, and 5 mg/kg/day of Paquinimod from week 10 of age until week 20 of age. Glycosuria is analyzed on a weekly basis from 10 weeks of age until the endpoint of the experiment at 40 weeks of age. There is a clear dose-dependent reduction in diabetes development in the Paquinimod-treated mice.
1-(4-硝基苯基偶氮)-2-萘酚; 1-((4-硝基苯基)二氮烯基)萘-2-醇; 1-(4-硝基苯基偶氮)萘-2-醇; 對位紅; 1-(4-NITROPHENYLAZO)-2-NAPHTHOL; 1-((4-Nitrophenyl)diazenyl)naphthalen-2-ol; Para Toner; Para Red Toner; Fast Rose Red Lake; PIGMENT RED 1; CIPIGMENTRED1; 2-Naphthalenol, 1-[(4-nitrophenyl)azo]-; 1-((4-nitrophenyl)azo)-2-naphthaleno; 1-((4-nitrophenyl)azo)-2-naphtho; 1-[(4-nitrophenyl)azo]-2-naphthaleno; 1-(P-NITROPHENYLAZO)-2-NAPHTHOL; 1-[(4-nitrofenyl)diazenyl]-2-naftol
