- 英文名称
- Parasin I
- 分子式
- C82H154N34O24
- 分子量
- 2000.31
- 中文别名
- 鲶鱼抗菌肽 I; KS-19; (2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,41S,44S,50S,56S)-56,60-diamino-41-(3-amino-3-oxopropyl)-14,20,32,44-tetrakis(4-aminobutyl)-8,26,50-tris(3-guanidinopropyl)-11-((R)-1-hydroxyethyl)-2,5-bis(hydroxymethyl)-29-isopropyl-17,23-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55-octadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54-octadecaazahexacontan-1-oic acid; L-Lysylglycyl-L-arginylglycyl-L-lysyl-L-glutaminylglycylglycyl-L-lysyl-L-valyl-L-arginyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-threonyl-L-arginyl-L-seryl-L-serine; KGRGKQGGKVRAKAKTRSS; LYS-GLY-ARG-GLY-LYS-GLN-GLY-GLY-LYS-VAL-ARG-ALA-LYS-ALA-LYS-THR-ARG-SER-SER; H-LYS-GLY-ARG-GLY-LYS-GLN-GLY-GLY-LYS-VAL-ARG-ALA-LYS-ALA-LYS-THR-ARG-SER-SER-OH; L-Serine, L-lysylglycyl-L-arginylglycyl-L-lysyl-L-glutaminylglycylglycyl-L-lysyl-L-valyl-L-arginyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-threonyl-L-arginyl-L-seryl-
- 用途
- Parasin I 是一种由19个氨基酸残基组成的多肽，源于从鲶鱼皮肤分离到的组蛋白H2A，具有抗菌作用，体外研究显示其可定位细胞膜并渗透外膜和胞质膜，与活性类似物有强胞质膜渗透活性；经密码子优化与人类溶菌酶融合后在毕赤酵母中表达，具有强效抗菌活性；鲶鱼抗菌肽I从皮肤粘液分离，序列与其他抗菌肽相同，抗菌谱广，无溶血活性，对特异性致病菌抗菌活性良好。
