- 英文名称
- 4-(5,7,7,10,10-Pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid
- 分子式
- C29H29N3O4
- 分子量
- 483.56
- 中文别名
- HX531; HX 531; 4-(7,8,9,10-四氢-5,7,7,10,10-五甲基-2-硝基-5H-苯并[B]萘并[2,3-E][1,4]二氮杂卓-12-基)苯甲酸; HX531; HX 531; HX-531; 4-(5,7,7,10,10-pentamethyl-2-nitro-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid; 4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid; Benzoic acid, 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-
- 用途
- 化学合成；HX531是一种口服有效的RXR拮抗剂，其IC50为18 nM，有抗黑色素瘤活性。HC531可消除全反式维甲酸(t-RA)的抗凋亡作用，并通过瘦素依赖途径和p53-p21Cip1通路，发挥抗肥胖和抗糖尿病作用并导致G0/G1细胞周期阻滞。
