- 英文名称
- Isocurcumenol
- 分子式
- C15H22O2
- 分子量
- 234.33
- 中文别名
- 异莪术醇; (3S,3AS,6R,8AS)-3-甲基-8-亚甲基-5-(丙-2-亚基)八氢-6H-3A,6-环氧薁-6-醇; (+)-Isocurcumenol; (3S,8aβ)-1,2,3,4,5,7,8,8a-Octahydro-3α-methyl-8-methylene-5-(1-methylethylidene)-6H-3aα,6α-epoxyazulen-6-ol; isourecumenol; 6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-, (3S,3aS,6R,8aS)-; (3S,3aS,6R,8aS)-3-Methyl-8-methylene-5-(propan-2-ylidene)octahydro-6H-3a,6-epoxyazulen-6-ol; 3S-(3α,3aα,6α,8aβ)-octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-6H-3a,6-epoxyazulen-6-ol; 6H-3A,6-EPOXYAZULEN-6-OL,OCTAHYDRO-3-METHYL-8-METHYLENE-5-(1-METHYLETHYLIDENE)-, (3S,3AS,6R,8AS)-; 3S-(3alfa,3aalfa,6alfa,8abeta)-octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-6H-3a,6-epoxyazulen-6-ol; (3a,3aα,6α,8aβ)-5-isopropylidene-3-methyl-8-methylene-3a,6-epoxyperhydroazulen-6-ol; (1S,2S,5S,8R)-9-Isopropylidene-2-methyl-6-methylene-11-oxa-tricyclo[6.2.1.01,5]undecan-8-ol; isocurcomenol; 9-Isopropylidene-2-methyl-6-methylene-11-oxatricyclo[6.2.1.0]undecan-8-ol
- 用途
- - 属性
莪术烯醇具有显著的抗炎作用，能够显著抑制由脂多糖刺激引起的巨噬细胞中NO的产生。莪术烯醇属于愈创木烷型倍半萜，是五元环与七元环相互骈合的结构，但由于其水溶性很差，易溶于乙酸乙酯、氯仿等小极性有机溶剂中，影响了其制剂的形成和药物开发。
- 作用
异莪术烯醇具有行气破血、消积止痛之功效，用于瘀血经闭、食积腹胀等，是临床上较为常用的活血化瘀药物。
- 生物活性
Isocurcumenol 可从 Curcuma zedoaria Rhizomes 中分离得到，是 ERα 的抑制剂。具有抗肿瘤活性。其对 DLA 和 KB 癌细胞的 IC50 分别为 99.1 µg/mL 和 178.2 µg/mL。
- 体外研究
Isocurcumenol (12.5-400 µg/mL, 24-48 h) dose-dependently inhibits cancer cells proliferation.
isocurcumenol does not exhibit any significant toxicity on normal chicken embryo fibroblast cells and lymphocytes.
- 用于含量测定/鉴定/药理实验等。
