- 英文名称
- CI-966 hydrochloride
- 分子式
- C23H22ClF6NO3
- 分子量
- 509.87
- 中文别名
- 化合物CI-966 hydrochloride; 3-吡啶羧酸,1-[2-[双[4-(三氟甲基)苯基]甲氧基]乙基]-1,2,5,6-四氢-,盐酸盐(1:1); 1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid hydrochloride; 1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride; 1-(2-(bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride; 1-{2-[Bis(4-(trifluoromethyl)phenyl)methoxy]ethyl}-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride; 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-(2-(bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-, hydrochloride; 1-(2-(Bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride; CI 966 hydrochloride; CI966; CI-966 (hydrochloride); Cl-966; 1-(2-{bis[4-(trifluoromethyl)phenyl]methoxy}ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride; 1-(2-(BIS(4-(TRIFLUOROMETHYL)PHENYL)METHOXY)ETHYL)-1,2,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLIC ACID MONOHYDROCHLORIDE; 1-(2-{Bis[4-(trifluoromethyl)phenyl]methoxy}ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid--hydrogen chloride (1/1); 1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID; CI 966 hydrochlorid
- 用途
- 化学合成；CI-966 hydrochloride 是有效、选择性、口服活性且可透过血脑屏障的 GABA 转运蛋白 GAT-1 抑制剂，抑制 hGAT-1 和 rGAT-1 的 IC50 分别为 0.26 μM 和 1.2 μM，对 GAT-1 的选择性比 GAT-2、GAT-3 和 BGT-3 高 200 倍以上，具有抗惊厥和神经保护活性。
