- 英文名称
- Canagliflozin hemihydrate
- 分子式
- C48H52F2O11S2
- 分子量
- 907.05
- 中文别名
- 坎格列净半水合物; 卡格列净半水; 坎格列净半水; 卡格列净半水物; 坎格列净半水化合物; 坎格列嗪半水物; 坎格列嗪半水合物; (2S,3R,4R,5S,6R)-2-(3-((5-(4-氟苯基)噻吩-2-基)甲基)-4-甲苯基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇 半水合物; Cagliflozin hemihydrate; Canagliflozin hydrate (2:1); D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, hydrate (2:1); Canagliflozin hemihydrates; (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate; (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hydrate (2:1); Cageline; (2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol,hydrate; TA-7284; (1S)-1,5-Anhydro-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol hydrate (2:1); canagliflozin hydrate; D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-, hydrate (2:1); Invokana; Canagliflozin (hemihydrate)
- 用途
- 生命科学，信号转导通路激酶抑制剂；医药，用于治疗糖尿病。坎格列净半水合物是SGLT-2抑制剂，对hSGLT2的IC50值为2.2 nM，对hSGLT2的选择性是对hSGLT1的413倍，可通过抑制肾脏对葡萄糖的重吸收使过量葡萄糖从尿液排出，降低血糖水平，用于治疗II型糖尿病。
