- 英文名称
- Argatroban
- 分子式
- C23H36N6O5S
- 分子量
- 508.63
- 中文别名
- (2R,4R)-1-((2S)-5-胍基-2-(3-甲基-1,2,3,4-四氢喹啉-8-磺胺基)戊酰基)-4-甲基哌啶-2-羧酸; (2R,4R)-4-甲基-1-[N-[(3-甲基-1,2,3,4-四氢-8-喹啉基)磺酰]-L-精氨酰]-2-哌啶甲酸; (2R,4R)-1-[5-[(氨基亚氨基甲基)氨基]-1-氧代-2-[[(1,2,3,4-四氢-3-甲基-8-喹啉基)磺酰基]氨基]戊基]-4-甲基-2-哌啶羧酸; 阿各卓泮; 阿戈托班; (2R,4R)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic acid; Argatroban anhydrous; Novastan; (2R,4R)-4-Methyl-1-{N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]arginyl}-2-piperidinecarboxylic acid; (2R,4R)-4-Methyl-1-{N-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]arginyl}piperidine-2-carboxylic acid; (2R,4R)-1-{N-(Diaminomethylene)-N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-ornithyl}-4-methyl-2-piperidinecarboxylic acid; (2R,4R)-1-{N-(diaminomethylidene)-N-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-ornithyl}-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-(5-Carbamimidamido-2-{[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]amino}pentanoyl)-4-methyl-2-piperidinecarboxylic acid; MQPA; Argipidine; (2R,4R)-4-Methyl-1-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic Acid; Slonnon; Argatroban (Mixture of Diastereomers); Argatroban（mixture of isomers）; ARG025
- 用途
- 生命科学领域作为直接、选择性的thrombin抑制剂，具有抗凝活性；人工合成抗凝血药，可逆竞争性凝血酶抑制剂，抑制凝血酶诱导的血小板聚集；用于缺血性脑梗死急性期、动脉血栓形成、急性心肌梗死血栓治疗及经皮冠状动脉手术辅助治疗；用于慢性动脉闭塞症；用于抗凝血酶III缺乏患者血透时的抗凝处理；用于治疗和预防肝素诱导的血栓栓塞及血小板减少症。
