- 英文名称
- Tetrahydrocoptisine
- 分子式
- C19H17NO4
- 分子量
- 323.34
- 中文别名
- 6,7,12b,13-四氢-4H-[1,3]二氧杂环戊烯并[4',5':7,8]异喹啉并[3,2-a][1,3]二氧杂环戊烯并[4,5-g]异喹啉; 人血草碱; 刺罂粟碱; 延胡索丁素; 6,7,12b,13-Tetrahydro-4H-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinoline; (.+-.)-Tetrahydrocoptisine; (-)-STYLOPINE; Chelidamine; Trahydocoptisine; DL-Stylopine; DL-Tetrahydrocoptisine; (±)-2,3:9,10-Bis(methylenedioxy)berbine; (RS)-Stylopine; (12bR)-6,7,12b,13-Tetrahydro-4H-bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizine; 6,7,12b,13-Tetrahydro-4H-bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizine
- 用途
- 具有较强的抗炎、抗内毒素休克作用，抗炎机制可能与抑制炎性物质的渗出和炎症细胞因子的分泌有关；可明显提高内毒素休克小鼠存活率，30mg／kg剂量组存活率达70％；可显著抑制内毒素休克小鼠血清中TNF-α的含量，并呈剂量依赖性；可降低LPS刺激引起的nitric oxide (NO)、prostaglandin E2 (PGE2)、tumor necrosis factor-alpha (TNF-alpha)、interleukin-1beta (IL-1beta)和IL-6的生成，以及cyclooxygenase-2 (COX-2)的活性
