- 英文名称
- Cynaropicrin
- 分子式
- C19H22O6
- 分子量
- 346.37
- 中文别名
- (3aR,4S,6aR,8S,9aR,9bR)-8-羟基-3,6,9-三亚甲基-2-氧代十二氢甘菊环并[4,5-b]呋喃-4-基 2-(羟甲基)丙烯酸酯; (3aR,4S,6aR,8S,9aR,9bR)-8-Hydroxy-3,6,9-trimethylene-2-oxododecahydroazuleno[4,5-b]furan-4-yl 2-(hydroxymethyl)acrylate; cynaporicrin; (8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl) 2-(hydroxymethyl)prop-2-enoate; cynatratoside B; 2-Hydroxymethylpropenoic acid (3aR,4S,6aβ,9aβ,9bα)-dodecahydro-8α-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester; Cynaropikrin; [(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] 2-(hydroxymethyl)prop-2-enoate; 2-methylolacrylic acid [(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-2-keto-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] ester; 2-Propenoic acid, 2-(hydroxymethyl)-, (3aR,4S,6aR,8S,9aR,9bR)-dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester
- 用途
- Cynaropicrin是一种倍半萜内酯，可抑制肿瘤坏死因子(TNF-α)的释放，在鼠和人巨噬细胞的IC50值分别为8.24和3.18μM；抑制软骨降解因子(MMP13)的增加并抑制NF-κB的信号传导；对刀豆蛋白A、植物血凝素、脂多糖诱导的有丝分裂信号有显著抑制作用，IC50值分别为1.20、1.02和0.90μM；以剂量依赖方式抑制CTLL-2细胞增殖，IC50为0.91μM；抑制TNF-α诱导的MMP13 mRNA表达增加；抑制IL-1β诱导的SW1353细胞中HIF-2α mRNA表达增加
