- 生物活性
Cirsiliol是有效和选择性的5-脂氧合酶 (5-lipoxygenase) 抑制剂，并且是竞争性低亲和力的苯二氮卓受体配体。
- 靶点
5-Lipoxygenase
- 体外研究
In concentrations from 0.01 to 300 μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca
2+
influx but stimulates Ca
2+
release from intracellular stores. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression.
- 体内研究
In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone.
