- 英文名称
- Isocryptotanshinone
- 分子式
- C19H20O3
- 分子量
- 296.36
- 中文别名
- 异丹参酮 III; (S)-4,4,8-Trimethyl-1,2,3,4,8,9-hexahydrophenanthro[3,2-b]furan-7,11-dione; 4,4,8-Trimethyl-2,3,8,9-tetrahydro-1H,4H-10-oxa-cyclopenta[b]phenanthrene-7,11-dione; (8S)-4,4,8-trimethyl-2,3,8,9-tetrahydro-1H-naphtho(2,1-f)(1)benzofuran-7,11-dione; (8S)-1,2,3,4,8,9-hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione; (+)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione; Isotanshinone III; Phenanthro[3,2-b]furan-7,11-dione, 1,2,3,4,8,9-hexahydro-4,4,8-trimethyl-, (8S)-; Isocryptotanshinon
- 用途
- 生命科学；中草药成分，是一种有效的信号传导与转录激活因子3 (STAT3) 和蛋白酪氨酸磷酸酶1 B (PTP1B) 的抑制剂。- 生物活性：Isocryptotanshinone 是一种有效的信号传导与转录激活因子3 (STAT3) 和蛋白酪氨酸磷酸酶1 B (PTP1B) 的抑制剂，其对 PTP1B 的 IC50 值为 56.1 μM。- 靶点：STAT3、PTP1B。- 体外研究：It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner.
