- 英文名称
- Neurodazine
- 分子式
- C58H79N19O10S2
- 分子量
- 1266.5
- 中文别名
- (4R,10S,13S,16R,19S,22S,25S,28R)-28-乙酰氨基-25-丁基-13,22-二(3-亚氨基甲酰胺基丙基)-19-(1H-咪唑-4-基甲基)-10-(1H-吲哚-3-基甲基)-16-(2-萘基甲基)-6,9,12,15,18,21,24,27-八氧代-1,2-二硫杂-5,8,11,14,17,20,23,26-八氮杂环二十九烷-4-甲酰胺; 化合物HS 024; MC4受体拮抗剂HS024; hs 024; (4R,10S,13S,16R,19S,22S,25S,28R)-28-Acetamido-25-butyl-13,22-bis(3-carbamimidamidopropyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthylmethyl)-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide; AC-CYS-NLE-ARG-HIS-D-2-NAL-ARG-TRP-GLY-CYS-NH2; (4R,10S,13S,16R,19S,22S,25S,28R)-28-acetamido-25-butyl-13,22-bis[3-(diaminomethylideneamino)propyl]-19-(1H-imidazol-5-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(naphthalen-2-ylmethyl)-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octazacyclononacosane-4-carboxamide; L-Cysteinamide, N-acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-, cyclic (1-->9)-disulfide; N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide; (ACETYL-CYS3,NLE4,ARG5,D-2-NAL7,CYS11)-ALPHA-MSH (3-11) AMIDE; AC-CYS-NLE-ARG-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-NH2; (AC-CYS3,NLE4,ARG5,D-ALA(2-NAPHTHYL)7,CYS11)-ALPHA-MSH (3-11) AMIDE; [Acetyl-Cys3, Nle4, Arg5, D-2-Nal7, Cys11]-α-Melanocyte Stimulating Hormone Fragment 3-11 amide
- 用途
- 化学合成；HS024是一种选择性的MC4受体拮抗剂，对MC4、MC5、MC3和MC1的Ki分别为0.29、3.29、5.45和18.6 nM，可增加食物摄入。
