- 英文名称
- 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid
- 分子式
- C6H5N5O3
- 分子量
- 195.14
- 中文别名
- 3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-羧酸; 替莫唑胺酸; 替莫唑胺-8-羧酸; 替莫唑胺杂质1; 替莫唑胺EP杂质B; 替莫唑胺杂质B; 替莫䂳胺酸; Temozolomideacid; 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxylic acid; Temozolomide-8-carboxylic acid; 3,4-Dihydro-3-Methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic Acid; 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid; Temozolomide Impurity 1; Temozolomide Impurity C; Temozolomide Acid; 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid
- 用途
- 3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-羧酸是Temozolomide（替莫唑胺）的羧酸衍生物，具有抗癌活性，可用于胶质母细胞瘤和脑癌的研究。替莫唑胺是一种DNA烷基化剂，通过使DNA的鸟嘌呤和腺嘌呤碱基甲基化，导致DNA双链断裂、细胞周期阻滞，最终引起细胞死亡。
