- 英文名称
- Xanthatin
- 分子式
- C15H18O3
- 分子量
- 246.3
- 中文别名
- 叶黄制菌素; (3aR,7S,8aS)-7-甲基-3-亚甲基-6-((E)-3-氧代丁-1-烯-1-基)-3,3a,4,7,8,8a-六氢-2H-环庚并[b]呋喃-2-酮; (3aR,7S,8aS)-7-Methyl-3-methylene-6-((E)-3-oxobut-1-en-1-yl)-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one; (3aR,7S,8aS)-7-methyl-3-methylidene-6-[(E)-3-oxobut-1-enyl]-4,7,8,8a-tetrahydro-3aH-cyclohepta[b]furan-2-one; 8-epi-Xanthatin; (3aR,7S,8aS)-7-Methyl-3-methylene-6-[(1Z)-3-oxo-1-buten-1-yl]-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one; [3aR-(3aa,7b,8ab)]-3,3a,4,7,8,8a-Hexahydro-7-methyl-3-methylene-6-(3-oxo-1-butenyl)-2H-cyclohepta[b]furan-2-one; 2H-Cyclohepta[b]furan-2-one,3,3a,4,7,8,8a-hexahydro-7-Methyl-3-Methylene-6-(3-oxo-1-buten-1-yl)-,(3aR,7S,8aS)-; (3aR)-3,3aα,4,7,8,8aβ-Hexahydro-7β-methyl-3-methylene-6-(3-oxo-1-butenyl)-2H-cyclohepta[b]furan-2-one; (3aR)-3-Methylene-7β-methyl-6-(3-oxo-1-butenyl)-3,3aα,4,7,8,8aβ-hexahydro-2H-cyclohepta[b]furan-2-one; 2H-Cyclohepta[b]furan-2-one, 3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-[(1E)-3-oxo-1-buten-1-yl]-, (3aR,7S,8aS)-; ( - ) - xanthatin
- 用途
- (3aR,7S,8aS)-7-甲基-3-亚甲基-6-((E)-3-氧代丁-1-烯-1-基)-3,3a,4,7,8,8a-六氢 2H-环庚并[b]呋喃-2-酮（苍耳亭）用于含量测定、鉴别、药理实验、活性筛选等；具有抗菌、消炎、祛风散热、除湿解毒作用；在体内外实验中显示较强抗肿瘤活性，显著抑制非小细胞肺癌及乳腺癌生长，对正常细胞影响小；诱导细胞凋亡，抑制PGE2合成和5-脂氧合酶活性发挥抗炎作用；抑制布鲁氏菌（IC50 2.63μg/mL），对锥虫硫磷还原酶有不可逆弱抑制作用；抑制VEGFR2激酶（IC50 3.8μM）、T.b.brucei（IC50 2.63μg/mL）；抑制肿瘤血管生成，体内实验抑制肿瘤体积且耐受性良好
