- 英文名称
- Thiolutin
- 分子式
- C8H8N2O2S2
- 分子量
- 228.29
- 中文别名
- N-(4-甲基-5-氧代-4,5-二氢-[1,2]二硫杂环戊烯并[4,3-b]吡咯-6-基)乙酰胺; 硫藤黄菌素; 硫鲁汀; N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide; acetopyrrothine; N-(4-Methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide; N-(4-methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-acetamide; 6-(Acetylamino)-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one; 6-Acetamido-4-methyl-1,2-dithiolo<4,3-b>pyrrol-5(4H)-on; Acetopyrrothin; 6-Acetamido-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one; 6-(Acetamido)-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one; 3-Acetamido-5-methylpyrrolin-4-one[4,3-d]-1,2-dithiole; N-(4-Methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-acetamid; 3-Acetamido-5-methylpyrrolin-4-one(4,3-d)-1,2-dithiole; 6-acetylamino-4-methyl-4H-[1,2]dithiolo[4,3-b]pyrrol-5-one; THIOLUTIN; N-(4,5-DIHYDRO-4-METHYL-5-OXO-1,2-DITHIOLO[4,3-B]PYRROL-6-YL)ACETAMIDE; THIOLUTIN (ACETOPYRROTHIN); N-acetylpyrrothine, Farcinicine, Acetopyrrothine; N-(5-keto-4-methyl-dithiolo[4,3-b]pyrrol-6-yl)acetamide
- 用途
- 有效和选择性内皮细胞粘附的抑制剂，可快速诱导热休克蛋白β-1 (Hsp27)磷酸化；抑制JAB1/MPN/Mov34 (JAMM)金属蛋白酶Csn5、SHAM-Domain-of-STAM (AMSH)相关的分子以及特异性去泛素酶Brcc36；是含二硫化物的抗生素和抗血管化合物；口服-小鼠LD50:25毫克/公斤；可燃，加热分解释放有毒氮氧化物和硫氧化物烟雾；库房通风低温干燥；灭火剂为干粉、泡沫、砂土、二氧化碳、雾状水
