- 英文名称
- Telithromycin
- 分子式
- C43H65N5O10
- 分子量
- 812
- 中文别名
- 红霉酮; 特利霉素; 红霉素酮; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(二甲基氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-4-乙基-11-甲氧基-3a,7,9,11,13,15-六甲基-1-(4-(4-(吡啶-3-基)-1H-咪唑-1-基)丁基)八氢-2H-[1]氧杂环十四碳烯并[4,3-d]恶唑-2,6,8,14(1H,7H,9H)-四酮; KETEK; HMR 3647; RU 66647; TELITHROMYCIN; (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-Methoxy-3a,7,9,11,13,15-hexaMethyl-1-[4-[4-(3-pyridinyl)-1H-iMidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)tetrone; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)butyl)octahydro-2H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetraone; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside; 3-De((2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy)-11,12-dideoxy-6-O-methyl-3-oxo-12,11-(oxycarbonyl((4-(4-(3-pyridinyl)-1H-imidazol-1-yl)butyl)imino))erythromycin
- 用途
- 大环内酯类抗生素，用于治疗呼吸道感染、支气管炎、咽炎、扁桃体炎、肺炎等；作用机制为抑制细菌核糖体50S亚基蛋白质合成，对耐药菌株有效；口服生物利用度约57%，经CYP3A4代谢，肝功能不全者需注意。
