- 英文名称
- TC14012
- 分子式
- C90H140N34O19S2
- 分子量
- 2066.42
- 中文别名
- TC 14012; TC 14012,拟肽CXCR4拮抗剂; 化合物TC14012; L-精氨酰-L-精氨酰-3-(2-萘基)-L-丙氨酰-L-半胱氨酰-L-酪氨酰-N5-(氨基羰基)-L-鸟甲基-L-赖氨酰-N5-(氨基羰基)-D-鸟基-L-脯氨酰-L-酪氨酰-L-精氨酰-N5-(氨基羰基)-L-鸟基-L-半胱氨酰-L-精氨酰胺环状(4→13)-二硫化物; H-ARG-ARG-{D-2-NAL}-CYS-TYR-CIT-LYS-{D-CIT}-PRO-TYR-ARG-CIT-CYS-ARG-NH2(DISULFIDE BRIDGE:CYS4-CYS13); 激动剂多肽TC14012; 化合物 TC14012; Tc 14012; L-Arginyl-L-arginyl-N-[(3S,6S,9R,12R,17R,20S,23S,26S,29S,34aS)-26-(4-aminobutyl)-12-{[(2S)-1-amino-5-carbamimidamido-1-oxo-2-pentanyl]carbamoyl}-6-(3-carbamimidamidopropyl)-9,23,29-tris[3-(carbamoylamino)propyl]-3,20-bis(4-hydroxybenzyl)-1,4,7,10,18,21,24,27,30-nonaoxotriacontahydro-1H,16H-pyrrolo[2,1-p][1,2,5,8,11,14,17,20,23,26,29]dithianonaazacyclodotriacontin-17-yl]-3-(2-naphthyl)-L-alaninamide; L-Alaninamide, L-arginyl-L-arginyl-N-[(3S,6S,9R,12R,17R,20S,23S,26S,29S,34aS)-26-(4-aminobutyl)-12-[[[(1S)-1-(aminocarbonyl)-4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-9,23,29-tris[3-[(aminocarbonyl)amino]propyl]-6-[3-[(aminoiminomethyl)amino]propyl]triacontahydro-3,20-bis[(4-hydroxyphenyl)methyl]-1,4,7,10,18,21,24,27,30-nonaoxo-1H,16H-pyrrolo[2,1-p][1,2,5,8,11,14,17,20,23,26,29]dithianonaazacyclodotriacontin-17-yl]-3-(2-naphthalenyl); L-Argininamide, L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-N5-(aminocarbonyl)-D-ornithyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4→13)-disulfide; TC 14012, Peptidomimetic CXCR4 antagonist
- 用途
- 化学合成；作为T140的血清稳定衍生物，是选择性CXCR4拮抗剂（IC50为19.3 nM）；有效CXCR7激动剂，可募集β-arrestin2到CXCR7（EC50为350 nM）；具有抗HIV活性和抗癌活性
