- 英文名称
- Sitagliptin phosphate monohydrate
- 分子式
- C16H20F6N5O6P
- 分子量
- 523.32
- 中文别名
- 磷酸西他列汀; 磷酸西他司汀; 磷酸西他列汀一水; 西他列汀磷酸一水合物; 磷酸西格列汀; 一水合磷酸西他列汀; (R)-3-氨基-1-(3-(三氟甲基)-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基)-4-(2,4,5-三氟苯基)丁-1-酮磷酸盐水合物; Sitagliptin phosphate hydrate; 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate; 3(R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H [1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate; (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogenphosphate monohydrate; Sitagliptin monohydrate; Sitagliptin Phosphate.H2O; Sitagliptin Monophosphate Monohydrate; (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate; Sitaglipin Phosphate Monohydrate; (R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate; 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate, hydrate (1:1:1); (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate hydrate (1:1:1); Sitagliptin Phosphate; Sitagliptin (phosphate monohydrate)
- 用途
- 磷酸西他列汀（商品名Januvia）是美国Merck公司生产的二肽基肽酶Ⅳ(DDP-4)抑制剂类药物，用于治疗2型糖尿病，具有血糖依赖性、无低血糖、不增加体重等优势，通过抑制DPP-4提高血浆中GLP-1和GIP活性，触发胰腺提高胰岛素生产并使肝脏停止葡萄糖生产，降低血糖浓度。
