- 英文名称
- Reveromycin B
- 分子式
- C36H52O11
- 分子量
- 660.79
- 中文别名
- 雷弗霉素B; (2E,4S,5S,6E,8E)-10-((2R,5S,7R,8S)-2-Butyl-2-((S,2E,4E)-5-carboxy-1-((3-carboxypropanoyl)oxy)-4-methylpenta-2,4-dien-1-yl)-8-methyl-1,6-dioxaspiro[4.5]decan-7-yl)-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid; 10-(2-butyl-2-hexa-2,4-dienyl-8-methyl-1,10-dioxaspiro[4.5]decan-9-yl)-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid; (2E,4S,5S,6E,8E)-10-[(2R,5S,8S,9R)-2-butyl-2-[(1S,2E,4E)-5-carboxy-1-(3-carboxypropanoyloxy)-4-methylpenta-2,4-dienyl]-8-methyl-1,10-dioxaspiro[4.5]decan-9-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid; Butanedioic acid, 1-[(1S,2E,4E)-1-[(2R,5S,7R,8S)-2-butyl-7-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-8-methyl-1,6-dioxaspiro[4.5]dec-2-yl]-5-carboxy-4-methyl-2,4-pentadien-1-yl] ester
- 用途
- 雷弗霉素B是一种螺旋缩酮细菌代谢物，最初从链霉菌中分离出来。它可抑制Balb/MK细胞中EGF诱导的有丝分裂活性（IC50=6 μg/mL），并表现出针对白色念珠菌的pH依赖性抗真菌活性（在pH 3.0和7.4时，MIC分别为15.6和>500 μg/mL）。与瑞维霉素A和瑞维霉素C不同，Reveromycin B不会抑制KB和K562细胞的增殖。
