- 英文名称
- Podocarpic acid
- 分子式
- C17H22O3
- 分子量
- 274.36
- 中文别名
- 罗汉松酸; 1,4A-DIMETHYL-6-HYDROXY-1,2,3,4A,9,10,10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID; 12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID; (1S,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid; 1,4-alpha-Dimethyl-6-hydroxy-1,2,3,4-alpha-9,10,10-alpha-octahydro-1-phenanthrenecarboxylicacid; 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S,4aS,10aR)-; 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI); (1S)-1,2,3,4,4aβ,9,10,10aα-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid; (1S)-1,4aβ-Dimethyl-6-hydroxy-1,2,3,4,4a,9,10,10aα-octahydrophenanthrene-1β-carboxylic acid; [1S,(+)]-1,2,3,4,4a,9,10,10aα-Octahydro-6-hydroxy-1,4aβ-dimethyl-1β-phenanthrenecarboxylic acid; (1R)-1,4aα-Dimethyl-6-hydroxy-1,2,3,4,4a,9,10,10aβ-octahydrophenanthrene-1α-carboxylic acid
- 用途
- 作为TRPA1的激活剂；其酸酐作为LXRalpha和beta受体的1nM激动剂，在HEK-293细胞中对LXR受体的激活效果比天然配体22-(R)-羟基胆固醇高8-10倍以上；激活秀丽隐杆线虫的SKN-1，与已知Nrf2激活剂α-硫辛酸作用相似，且激活依赖TRPA1；缓解glod-4动物的致病表型，将其内源性MGO和GO水平恢复至接近野生型。
