- 英文名称
- Neamine
- 分子式
- C12H26N4O6
- 分子量
- 322.36
- 中文别名
- (2R,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((1R,2R,3S,4R,6S)-4,6-二氨基-2,3-二羟基环己基)氧基)四氢-2H-吡喃-3,4-二醇; 硫酸新霉素杂质A; 新黴素A; 硫酸新霉素EP杂质A; 新霉素杂质A(EP); 新霉素杂质A; (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4-diol; (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL; 5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL; U-5214; 2-deoxy-4-o-(2,6-diamino-2,6-dideoxy-alpha-d-glucopyranosyl)-d-streptamin; 5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol; dekamycinv; neamin; (1R,2R,3S,4R,6S)-4,6-Diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside; 2-Deoxy-4-O-(2,6-diamine-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine; Neomycin A; Negamicin; neomycina; 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl)-D-streptamine; nebramycinx
- 用途
- - 新霉胺是新霉素的降解产物，是一种广谱氨基糖苷类抗生素。
- 生物活性
Neamine 是一种 Neomycin 的无毒衍生物，也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌，抗肿瘤和神经保护活性。
- 体外研究
Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM.
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively.
Cell Proliferation Assay
Cell Line:
AsPC-1 cells
Concentration:
0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM
Incubation Time:
48 hours
Result:
Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.
- 体内研究
Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.
Animal Model:
Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells
Dosage:
30 mg/kg, 60 mg/kg
Administration:
Subcutaneous injection; daily; for 14 days
Result:
Had anti-tumor effects on AsPC-1 xenograft models.
