- 英文名称
- Ilexhainanoside D
- 分子式
- C36H56O11
- 分子量
- 664.83
- 中文别名
- 冬青叶苷D; (3S,4R,4aR,6aR,6bS,8aR,12S,12aS,14aR,14bR)-3,12-二羟基-4,6a,6b,11,11,14b-六甲基-8a-((((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧)羰基)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-二十氢菲-4-羧酸; Olean-12-ene-23,28-dioic acid, 3,19-dihydroxy-, 28-β-D-glucopyranosyl ester, (3β,4β,19α)-; (3S,4R,6aR,6bS,8aR,12S,12aR,14aR,14bR)-3,12-Dihydroxy-4,6a,6b,11,11,14b-hexamethyl-8a-((((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid; (3S,4R,4aR,6aR,6bS,8aR,12S,12aS,14aR,14bR)-3,12-Dihydroxy-4,6a,6b,11,11,14b-hexamethyl-8a-((((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid; (3S,4R,4aR,6aR,6bS,8aR,12S,12aS,14aR,14bR)-3,12-dihydroxy-4,6a,6b,11,11,14b-hexamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4-carboxylic acid
- 用途
- 海南冬青苷D是从海南冬青（Ilex hainanensis Merr.）中提取的主要三萜皂苷，与冬青皂苷A1联合使用后具有抗炎作用；体内研究显示，该联合用药（60、120或240 mg/kg，持续8周）可剂量依赖性减轻高脂饮食诱导的非酒精性脂肪肝（NAFLD），降低厚壁菌门/拟杆菌门比例，减少脱硫弧菌属相对丰度，增加 Akkermansia 相对丰度，上调回肠中紧密连接蛋白ZO-1和occludin的表达以改善肠屏障，减少脂多糖（LPS）入血并降低肝脏促炎细胞因子基因表达。
