- 英文名称
- Enfumafungin
- 分子式
- C38H60O12
- 分子量
- 708.88
- 中文别名
- (1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aS)-3-乙酰氧基-13-羟基-1,6a,8,10a-四甲基-8-((R)-3-甲基丁-2-基)-2-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-十四氢-2H-1,4a-(甲氧基甲氧基)苯并菲-7-羧酸; 恩富马芬金; 恩麻芬净; (1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aS)-3-Acetoxy-13-hydroxy-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid; 4H-1,4a-Propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid, 14-(acetyloxy)-8-[(1R)-1,2-dimethylpropyl]-15-(β-D-glucopyranosyloxy)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-4-hydroxy-1,6a,8,10a-tetramethyl-, (1S,4aR,6aS,7R,8R,10aR,10bR,12aS,14R,15R)-; (1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aS)-3-acetoxy-13-hydroxy-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid; (1R,5S,6R,7R,10R,11R,14S,15S,20R,21R)-20-(acetyloxy)-18-hydroxy-5,7,10,15-tetramethyl-7-[(2R)-3-methylbutan-2-yl]-21-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-17-oxapentacyclo[13.3.3.01,1?.02,11.0?,1?]henicos-2-ene-6-carboxylic acid
- 用途
- 化学合成；作为(1,3)-beta-D-葡聚糖合酶抑制剂作用于真菌细胞壁，对酵母和真菌（隐球菌除外）具有特异性抗真菌活性；其半合成衍生物伊布瑞克芬格(ibrexafungerp)获FDA批准用于治疗侵袭性外阴念珠菌病；对测试的念珠菌和曲霉菌物种MIC小于0.5μg/mL，对隐球菌无活性；以50-200mg/kg腹腔注射小鼠可显著降低肾脏中白色念珠菌菌落数，ED90为90mg/kg
