- 英文名称
- dexrazoxane hydrochloride
- 分子式
- C11H17ClN4O4
- 分子量
- 304.73
- 中文别名
- 右丙亚胺盐酸盐; 右雷佐生盐酸盐; (S)-4,4'-(丙-1,2-二基)双(哌嗪-2,6-二酮)盐酸盐; 右雷佐生(右丙亚胺)盐酸盐; (S)-4,4'-(丙烷-1,2-二基)双(哌嗪-2,6-二酮) x盐酸盐; 化合物Cardioxane; Cardioxane; 2,6-Piperazinedione, 4-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-, hydrochloride (1:1); 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dionhydrochlorid; 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione chlorhydrate; (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedionehydrochloride; 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, hydrochloride (1:1); 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione) hydrochloride (1:1); 2,6-piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, monohydrochloride; 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione hydrochloride (1:1); Dexrazoxane HCl; Dexrazoxane (Hydrochloride); (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione hydrochloride; ICRF-187 hydrochloride; Totect; Cardioxan; Savene; ADR-529 hydrochloride; (+)-Razoxane hydrochloride; Razoxane hydrochloride, (S)-
- 用途
- 化学合成；生命科学；医药。用于减少接受累积盐酸阿霉素剂量达300 mg/m²且需继续阿霉素治疗的转移性乳腺癌女性患者阿霉素相关心肌病的发生率和严重程度；也批准用于治疗蒽环类药物静脉外渗。作为胞内铁螯合剂，减少氧自由基生成，抑制拓扑异构酶II，通过结合游离铁或松散结合的铁络合阿霉素，防止氧自由基产生，保护心肌细胞，减少组织病变。
