- 英文名称
- 7,8-Dihydro-2-methyl-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one
- 分子式
- C8H10N2OS
- 分子量
- 182.24
- 中文别名
- 1,5,7,8-四氢-2-甲基-4H-硫代吡喃[4,3-d]嘧啶-4-酮; 7,8-二氢-2-甲基-1H-噻喃[4,3-D]嘧啶-4(5H)-酮; 化合物DR2313; DR2313; 2-Methyl-1,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one; 3,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one; 2-methyl-3,5,7,8-tetrahydrothiopyrano(4,3-d)pyrimidine-4-one; DR 2313; 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE; 2-Methyl-1-sulfanyl-1H,4H,5H,7H,8H-pyrano[4,3-d]pyrimidin-4-one; SC-202756
- 用途
- 3,5,7,8-四氢-2-甲基-4H-硫代吡喃并[4,3-D]嘧啶-4-酮是一种有效，选择性，竞争性的和可透过血脑屏障的PARP抑制剂，抑制PARP-1和PARP-2的IC50值分别为0.20μM和0.24μM；在体外和体内均表现出对缺血性损伤的神经保护作用
