- 英文名称
- CCT241533 hydrochloride
- 分子式
- C23H28ClFN4O4
- 分子量
- 478.94
- 中文别名
- CCT 241533 盐酸盐; CHK2抑制剂; 化合物T10718L; 化合物CCT241533盐酸盐; 3-吡咯烷甲醇,4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-α,α-二甲基-,盐酸盐(1:1),(3R,4S)-rel-; rel-4-Fluoro-2-(4-(((3R,4S)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol hydrochloride; CCT241533 (hydrochloride); 4-Fluoro-2-(4-{[(3S,4R)-4-(2-hydroxy-2-propanyl)-3-pyrrolidinyl]amino}-6,7-dimethoxy-2-quinazolinyl)phenol hydrochloride (1:1); 3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, hydrochloride (1:1), (3R,4S)-; CCT-241533 hydrochloride; (3R,4S)-rel-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol hydrochloride (1:1); CCT241533 HCl; CCT 241533 HYDROCHLORIDE; 4-Fluoro-2-(4-(((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol hydrochloride
- 用途
- CCT241533 hydrochloride is a selective CHK2 inhibitor (IC50=3 nM, Ki=1.16 nM) with minimal cross-reactivity against kinases at 1 μM. It inhibits CHK2 autophosphorylation at S516, blocks CHK2 activity in tumor cells, and potentiates PARP inhibitor cytotoxicity. Its GI50 values in HT-29, HeLa, MCF-7 are 1.7, 2.2, 5.1 μM respectively.
