1431697-96-9 rel-4-氟-2-(4-(((3R,4S)-4-(2-羟基丙烷-2-基)吡咯烷-3-基)氨基)-6,7-二甲氧基喹唑啉-2-基)苯酚盐酸盐

运输信息：冰袋运输。危险描述：非危险化学品。

CCT241533 hydrochloride is a selective CHK2 inhibitor (IC50=3 nM, Ki=1.16 nM) with minimal cross-reactivity against kinases at 1 μM. It inhibits CHK2 autophosphorylation at S516, blocks CHK2 activity in tumor cells, and potentiates PARP inhibitor cytotoxicity. Its GI50 values in HT-29, HeLa, MCF-7 are 1.7, 2.2, 5.1 μM respectively.

生命科学; 医药