- 英文名称
- Conophylline
- 分子式
- C44H50N4O10
- 分子量
- 794.89
- 中文别名
- 长春碱衍生物; CONOPHYLLINE; 长春花碱 III-121C; 长春花生物碱III-121C; 化合物 T13624; 硫酸长春新碱杂质10; (−)-Conophylline;Dimethyl (1aS,1bS,6aS,7S,7aS,14bR,14cR,17aR,18bR,21aR,22aR)-1b,7a-diethyl-7,13-dihydroxy-11,12-dimethoxy-1b,4,6a,7,7a,8,10,14c,15,16,17a,19,20,21a,22,22a-hexadecahydro-1aH,2H-indolo[2'',3'':7',8']pyrrolo[1'',2'',3'':1',8']quinolino[2',3':4,5]furo[2,3-b]oxireno[6,7]indolizino[1,8-fg]carbazole-3,9-dicarboxylate; dimethyl (2R,6R,11R,13S,14S,23S,24S,25S,36R,39R,40R)-14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo[23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40]tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate; Cophylline; Vinca alkaloid III-121C; [8,15'-Biaspidospermidine]-3,3'-dicarboxylicacid,2,2',3,3'-tetradehydro-6',7':7,16'-diepoxy-6,15-dihydroxy-16,17-dimethoxy-,dimethyl ester, (5a,6b,7a,8a,12R,19a)-(5'a,6'b,7'b,12'R,19'a)-; [8,15'-Biaspidospermidine]-3,3'-dicarboxylic acid, 2,2',3,3'-tetradehydro-6',7':7,16'-diepoxy-6,15-dihydroxy-16,17-dimethoxy-, dimethyl ester, (5α,6β,7α,8α,12R,19α)-(5'α,6'β,7'β,12'R,19'α)-; Vincristine Impurity 10
- 用途
- 化学合成；作为胰腺细胞分化诱导剂，抑制肝星状细胞（HSC）并诱导其凋亡；体外实验显示在特定浓度和时间下可诱导分化和抑制DNA合成，促进caspase-3激活；体内实验表明口服给药可减轻肝纤维化。
