- 英文名称
- Banoxantrone
- 分子式
- C22H28N4O6
- 分子量
- 444.48
- 中文别名
- 拓扑异构酶II抑制剂; 2,2'-((5,8-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)bis(azanediyl))bis(N,N-dimethylethanamine oxide); 1,4-Bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione bis-N-oxide; 9,10-Anthracenedione, 1,4-bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-; 2-[[4-[2-[dimethyl(oxido)azaniumyl]ethylamino]-5,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]-N,N-dimethylethanamine oxide; 1,4-Bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-9,10-anthracenedione N,N'-dioxide; 1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione; AQ4N; 1,4-bis-{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroanthracene-9,10-dione; 1,4-bis-(2-dimethylamino-ethylamino)-5,8-dihydroxy-anthraquinone-bis-N-oxide; 1,4-Bis(2-(dimethylazinoyl)ethylamino)-5,8-dihydroxy-9,10-anthraquinone
- 用途
- 概述
Banoxantrone (AQ4N) 作为一种典型的缺氧选择性细胞毒素。Banoxantrone 可被还原为 AQ4，AQ4 是一种有效的拓扑异构酶 II 抑制剂。Banoxantrone 通过 iNOS 依赖机制选择性地杀死缺氧细胞。Banoxantrone 显示出强大的细胞毒性和低氧选择性效应，且能被辐射增强。
