- 英文名称
- Atazanavir-d6
- 分子式
- C38H46D6N6O7
- 分子量
- 710.89
- 中文别名
- 阿扎那韦-D5; 2H6-阿扎那韦; Atazanavir D6; [2H6]-Atazanavir; trideuteriomethyl N-[(2S)-1-[2-[(2S,3S)-3-[[(2S)-3,3-dimethyl-2-(trideuteriomethoxycarbonylamino)butanoyl]amino]-2-hydroxy-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate; Methyl-d3 ((5S,8S,9S,14S)-8-benzyl-5-(tert-butyl)-9-hydroxy-15,15-dimethyl-3,6,13-trioxo-11-(4-(pyridin-2-yl)benzyl)-2-oxa-4,7,11,12-tetraazahexadecan-14-yl-1,1,1-d3)carbamate; 2,5,6,10,13-Pentaazatetradecanedioic acid,3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-,1,14-di(methyl-d3) ester,(3S,8S,9S,12S); (3S,8S,9S,12S)-2,5,6,10,13-Pentaazatetradecanedioic acid 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-1,14-di(methyl-d3) ester
- 用途
- 阿扎那韦D6是Atazanavir氘代物，Atazanavir是高选择性HIV-1蛋白酶抑制剂，用于艾滋病毒感染研究，也是CYP3A4、P-糖蛋白的抑制剂和诱导剂，同时是SARS-CoV 3CLpro的抑制剂，IC50为3.49 μM。
