- 英文名称
- Arglabin
- 分子式
- C15H18O3
- 分子量
- 246.3
- 中文别名
- (1aS,3aS,6aS,6bR,9aR)-1a,7-二甲基-4-亚甲基代-2,3,3a,4,6b,9-六氢-1aH-环氧乙烯并[2',3':8,8a]薁并[4,5-b]呋喃-5(6aH)-酮; 小白菊内酯衍生物; (3aR,4aS,6aS,9aS,9bR)-1,4a-Dimethyl-7-methylene-5,6,6a,7,9a,9b-hexahydro-3H-oxireno[2',3':8,8a]azuleno[4,5-b]furan-8(4aH)-one; (+)-Arglabin; (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one; (3aR,4aS)-1,4aα-Dimethyl-7-methylene-4a,5,6,6aα,9aβ,9bα-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(7H)-one; (3aS)-2,3,3aβ,4,5β,6,6a,7,9aβ,9bα-Decahydro-6α,6aα-epoxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2-one; Arglabine
- 用途
- 中草药成分，具有抗炎和抗肿瘤活性；是NLRP3炎症小体抑制剂；抗肿瘤活性通过抑制法尼基转移酶激活RAS原癌基因实现，抑制法尼基焦磷酸通过该酶掺入人H-ras蛋白；在高脂饮食喂养的ApoE2.Ki小鼠中减少炎症和血浆脂质，增加自噬，使组织巨噬细胞向抗炎表型定向。
