- 英文名称
- Rocaglamide
- 分子式
- C29H31NO7
- 分子量
- 505.56
- 中文别名
- 洛克米兰酰胺; (1R,2R,3S,3aR,8bS)-1,8b-二羟基-6,8-二甲氧基-3a-(4-甲氧基苯基)-N,N-二甲基-3-苯基-2,3,3a,8b-四氢-1H-环戊二烯并[b]苯并呋喃-2-甲酰胺; (1R,2R,3S,3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide; (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide; (1R,2R,3S,3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-2-carboxamide; (1R)-2,3,3a,8b-Tetrahydro-1α,8bβ-dihydroxy-6,8-dimethoxy-3aβ-(4-methoxyphenyl)-N,N-dimethyl-3β-phenyl-1H-cyclopenta[b]benzofuran-2α-carboxamide; (1R)-N,N-Dimethyl-1α,8bβ-dihydroxy-3β-phenyl-3aβ-(4-methoxyphenyl)-6,8-dimethoxy-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2α-carboxamide; 2,3,3a,8b-Tetrahydro-1α,8bβ-dihydroxy-6,8-dimethoxy-3aβ-(4-methoxyphenyl)-N,N-dimethyl-3β-phenyl-1H-cyclopenta[b]benzofuran-2α-carboxamide; 2,3,3a,8b-Tetrahydro-N,N-dimethyl-1α,8bβ-dihydroxy-6,8-dimethoxy-3β-phenyl-3aβ-(4-methoxyphenyl)-1H-cyclopenta[b]benzofuran-2α-carboxamide; N,N-Dimethyl-1α,8bβ-dihydroxy-6,8-dimethoxy-3β-phenyl-3aβ-(4-methoxyphenyl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2α-carboxamide; (1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide
- 用途
- 生命科学领域作为有效的选择性热休克因子1(HSF1)活化抑制剂；中草药成分，具有抗炎、抗肿瘤、抗病毒等作用；天然化合物楝酰胺(Rocaglamide，简称Roc-A)是从Aglaia属植物中分离出来的抗肿瘤活性物质，与紫杉醇和喜树碱有相当的细胞毒性且对正常细胞无毒性，通过与翻译起始因子eIF4A结合抑制蛋白质合成；具有强效杀虫作用，活性与印楝素相当；可用于咳嗽、受伤、哮喘和炎症性皮肤病；是T细胞中有效的NF-κB活化抑制剂；抑制非小细胞肺癌细胞自噬，提高癌细胞对NK细胞杀伤作用的敏感性；抑制非小细胞肺癌细胞自噬的直接作用靶标为ULK1；增强TRAIL诱导的耐药HCC细胞凋亡，可使HepG2和Huh-7细胞对TRAIL治疗敏感；体内显著抑制肿瘤生长且无明显毒性
