- 生物活性
Bepridil hydrochloride是一种抗心绞痛的药物，是钙离子通道（calcium channel）阻滞剂。它能阻止多种其他离子通道，包括钠离子和钾离子通道。
- 靶点
Ca
2+
- 体外研究
Bepridil hydrochloride hydrate blockades of Ca
2+
-dependent action potentials in vascular smooth muscle of dog coronary artery.
Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC
50
s of 0.5 μM and 30 μM, respectively in cultured ventricular cells.
Bepridil hydrochloride hydrate decreases I
Ks
under blockade of I
Kr
with E4031 (5 μM), in a concentration-dependent manner.
- 体内研究
Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration.
