- 英文名称
- Nosiheptide
- 分子式
- C51H43N13O12S6
- 分子量
- 1222.35
- 中文别名
- 诺西肽; 诺肽菌素; 那西肽/诺肽菌素; N-(3-氨基-3-氧代丙-1-烯-2-基)-2-((11S,14Z,21S,23S,29S)-14-亚乙基-3,23-二羟基-11-((1R)-(1-羟乙基))-31-甲基-9,12,19,24,33,43-六氧代-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-十六氢-21,36-([2,4]-endo-thiazolomethanimino)-5,8:15,18:37,40-三(azeno)-30,32-epimino苯并[h1]吡啶并[3,2-v][1]氧杂[10,20,26,30]四硫杂[6,13,16]三氮杂环三十六烷-2-基)噻唑-4-甲酰胺; Multhiomycin; priMofax; N-[1-(Aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-4-thiazolecarboxamide; N-(3-Amino-3-oxoprop-1-en-2-yl)-2-((11S,14Z,21S,23S,29S)-14-ethylidene-3,23-dihydroxy-11-((1R)-(1-hydroxyethyl))-31-methyl-9,12,19,24,33,43-hexaoxo-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-21,36-([2,4]-endo-thiazolomethanimino)-5,8:15,18:37,40-tri(azeno)-30,32-epiminobenzo[h1]pyrido[3,2-v][1]oxa[10,20,26,30]tetrathia[6,13,16]triazacyclohexatriacontin-2-yl)thiazole-4-carboxamide
- 用途
- 作为动物生长饲料添加剂；体外对金黄色葡萄球菌（包括多重耐药菌株）、肠球菌及艰难梭菌 BI 菌株活性极强，MIC ≤ 0.25 mg/L，杀菌作用浓度和时间依赖性，对哺乳动物细胞无毒性且不受人血清抑制；体内腹腔注射给药（20 mg/kg，感染后 1 和 8 h 注射）可显著降低感染小鼠死亡率，10/10 存活至第 3 天，对照组 6/10 第 1 天死亡。
