- 英文名称
- AMD 070
- 分子式
- C21H27N5
- 分子量
- 349.47
- 中文别名
- (S)-N1-((1H-苯并[D]咪唑基-2-基)甲基)-N1-(5,6,7,8-四氢喹啉-8-基)丁烷-1,4-二胺; 化合物AMD-070; X4P-001; (S)-N1-((1H-苯并[D]咪唑-2-基)甲基)-N1-(5,6,7,8-四氢喹啉-8-基)丁烷-1,4-二胺; AMD-070 (AMD-11070); (S)-N1-[(2-苯并咪唑基)甲基]-N1-(5,6,7,8-四氢-8-喹啉基)-1,4-丁二胺; AMD-11070; N-(1H-benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI); N'-(1H-Benzimidazol-2-ylmethyl)-N'-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; 1,4-Butanediamine, N-(1H-benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-; (S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; AMD070; AMD-070; N'-(1H-benzimidazol-2-ylmethyl)-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine; N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine
- 用途
- 有效的、选择性的、可口服的CXCR4拮抗剂，能够拮抗125I-SDF与CXCR4结合，IC50值为13nM；能够抑制HIV-1（NL4.3株）的复制，在MT-4和PBMCs细胞中，IC50值分别为1nM和9nM
