- 英文名称
- Pladienolide B
- 分子式
- C30H48O8
- 分子量
- 536.7
- 中文别名
- (2S,3S,6S,7R,10R,E)-7,10-二羟基-2-((S,2E,4E)-7-((2R,3R)-3-((2R,3S)-3-羟基戊烷-2-基)环氧乙烷-2-基)-6-甲基庚-2,4-二烯-2-基)-3,7-二甲基-12-氧代氧杂环十二碳-4-烯-6-基 乙酸酯; 化合物 T16551; 铂B; 化合物Pladienolide B; (2S,3S,6S,7R,10R,E)-7,10-Dihydroxy-2-((S,2E,4E)-7-((2R,3R)-3-((2R,3S)-3-hydroxypentan-2-yl)oxiran-2-yl)-6-methylhepta-2,4-dien-2-yl)-3,7-dimethyl-12-oxooxacyclododec-4-en-6-yl acetate; (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-2-[(2E,4E,6S)-7-{(2R,3R)-3-[(2R,3S)-3-hydroxy-2-pentanyl]-2-oxiranyl}-6-methyl-2,4-heptadien-2-yl]-3,7-dimethyl-12-oxooxacyclododec-4-en-6-yl acetate; 11107B; 11107AD; (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one; Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)-
- 用途
- 普拉地内酯B是一种有效的癌细胞生长抑制剂，其作用靶向剪接体的SF3B1亚单位；通过抑制前mRNA剪接发挥抗肿瘤作用，诱导凋亡。
