- 英文名称
- 7-Cyclobutyl-3-(2,6-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
- 分子式
- C19H17F2N7O
- 分子量
- 397.38
- 中文别名
- MK-0343; MK 0343; 化合物MK-0343; 抑制剂MK 0343; 化合物T16084; 7-环丁基-3-(2,6-二氟苯基)-6-((1-甲基-1H-1,2,4-三氮唑-5-乙基)甲氧基)-[1,2,4]三氮唑[4,3-B]哒嗪; 7-环丁基-3-(2,6-二氟苯基)-6-[(1-甲基-1H-1,2,4-三氮唑-5-基)甲氧基]-1,2,4-三氮唑并[4,3-B]哒嗪; MK-0343; MK 0343; MK0343; MRK-409; 7-cyclobutyl-3-(2,6-difluorophenyl)-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-1,2,4-triazolo[4,3-b]pyridazine; 7-cyclobutyl-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2,6-difluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine; 1,2,4-Triazolo[4,3-b]pyridazine, 7-cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-Methyl-1H-1,2,4-triazol-5-yl)Methoxy]-; 7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine; 7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazo[4,3-b]pyridazine
- 用途
- 口服生物可利用的GABAA受体亚型选择性部分激动剂；非镇静的抗焦虑药物；在大鼠体内研究中，口服给药后能穿透脑部并占据GABAA受体的苯二氮䓬位点，Occ50为2.2mg/kg p.o.，对应血浆EC50为115ng/mL。
