- 英文名称
- Clindamycin Sulfoxide
- 分子式
- C18H33ClN2O6S
- 分子量
- 440.98
- 中文别名
- 亚砜克林霉素; Clindamycinsulfoxid; (2S,4R)-N-((1S,2S)-2-Chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfinyl)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide; (2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfinyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide; 7(S)Chloro-7-deoxylincomycin sulfoxide; U 25026A; 7-CHLORO-1,6,7,8-TETRADEOXY-6-((((2S,4R)-1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL)AMINO)-1-(METHYLSULFINYL)-L-THREO-.ALPHA.-D-GALACTO-OCTOPYRANOSE; 7-Chloro-1,6,7,8-tetradeoxy-6-((((2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-(methylsulfinyl)-L-threo-alpha-D-galacto-octopyranose; L-Threo-alpha-D-galacto-octopyranose, 7-chloro-1,6,7,8-tetradeoxy-6-((((2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-(methylsulfinyl)-; 7-Chloro-1,6,7,8-tetradeoxy-6-[[[(2S)-1-methyl-4β-propyl-2α-pyrrolidinyl]carbonyl]amino]-1-(methylsulfinyl)-α-L-threo-D-galacto-octopyranose; 7(S)-Chloro-7-deoxylincoMycin Sulfoxide; 7-Chloro-1,6,7,8-tetradeoxy-6-[[[(2S,4R)-1-Methyl-4-propyl-2-pyrrolidinyl]carbonyl]aMino]-1-(Methylsulfinyl)-L-threo-α-D-galactooctopyranose; Clindamycin Impurity 8; Clindamycin Impurity 30
- 用途
- 克林霉素亚砜是抗生素克林霉素的活性代谢物，主要通过细胞色素P450（CYP）同工酶CYP3A4对克林霉素进行S-氧化而形成。在体外抑制P. prevotti、B. fragilis和C. sordelli的生长，MIC值分别为2、2和1 mg/L。
