- 英文名称
- Ursocholic acid
- 分子式
- C24H40O5
- 分子量
- 408.58
- 中文别名
- 熊去氧胆酸EP杂质D; 3α,7β,12α-三羟基-5β-胆酸-24-油酸; 熊胆酸; 熊去氧胆酸杂质5; 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-三羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[A]菲-17-基]戊酸; 熊去氧胆酸杂质D; (R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-三羟基-10,13-二甲基十六氢-1H-环戊[a]菲-17-基)戊酸; 7-Epicholic Acid; 7β-Hydroxyisocholic Acid; (4R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; Ursocholate; Ursodeoxycholic Acid EP Impurity D; Chenodeoxycholic Acid EP Impurity D; 3α-Cholic Acid; 3α,7α,12α-Trihydroxy-5α-cholanoic Acid; 3-Epicholic acid; 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; (R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
- 用途
- 熊去氧胆酸是一种胆固醇结石溶解剂，能减少肝脏对胆固醇的分泌，降低胆汁中胆固醇的饱和度，促进胆汁酸分泌，增加胆固醇在胆汁中的溶解度，使胆固醇结石溶解或防止结石形成；可增加胆汁分泌量，松弛胆管口括约肌产生利胆作用，有利于结石排出；适用于治疗胆固醇性结石、高脂血症、胆汁分泌障碍性疾病、原发性胆汁性肝硬化、慢性肝炎、胆汁反流性胃炎和预防肝移植急性排斥反应。熊果胆酸为其杂质，溶石作用略弱于鹅去氧胆酸。
