- 英文名称
- Posaconazole Impurity 78
- 分子式
- C37H42F2N8O6
- 分子量
- 732.79
- 中文别名
- 泊沙康唑杂质50; 泊沙康唑氮氧化物杂质122; 泊沙康唑氮氧化物杂质1; 泊沙康唑杂质YH3; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-基甲基)氧杂戊环-3-基]甲氧基]苯基]-1,4-二氧-哌嗪-1-基]苯基]-2-[(2S,3S)-2-羟基戊-3-基]-1,2,4-三唑-3-酮; 泊沙康唑氮氧化物杂质; 泊沙康唑IMP24; Posaconazole Impurity 50; Posaconazole Piperazine Dioxide; Posaconazole Impurity P; 1-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-4-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)piperazine 1,4-dioxide; 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1,4-dioxido-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol; posaconazole N-Oxide impurity 1; posaconazole N-Oxide impurity; Posaconazole Impurity YH3; Posaconazole Dioxido Impurity
- 用途
- 化学合成；泊沙康唑作为第二代三唑类抗真菌药物，通过抑制真菌细胞膜麦角甾醇合成发挥抗真菌作用，适用于免疫功能严重低下的高风险人群真菌感染治疗，杂质78作为其合成中间体或相关研究用物质参与合成过程。
