- 英文名称
- SHU-9119
- 分子式
- C54H71N15O9
- 分子量
- 1074.24
- 中文别名
- 拮抗剂多肽SHU 9119; 化合物SHU 9119; AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2(CHEMICAL BRIDGE ASP2-LYS7); (3R,6R,9S,12R,15R,23R)-12-((1H-咪唑-5-基)甲基)-3-((1H-吲哚-3-基)甲基)-15-((R)-2-乙酰氨基己酰氨基)-6-(3-胍基丙基)-9-(萘-2-基甲基)-2,5,8,11,14,17-六氧代-1,4,7,10,13,18-六氮杂环二十三烷-23-甲酰胺; shu 9119; SHU9119; (3S,6S,9R,12S,15S,23S)-15-[(N-Acetyl-L-norleucyl)amino]-6-{3-[(diaminomethylene)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-9-(2-naphthylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide; [N-ACETYL-NLE4,ASP5,D-2'-NAL7,LYS10]-ALPHA-MSH (4-10) AMIDE, ASP5-LYS10, CYCLIC LACTAM; AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2; AC-NLE-ASP-HIS-D-2'-NAL-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM; AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG; AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2; (AC-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE; AC-[NLE4, ASP5, D-2-NAL7, LYS10]-CYCLO-ALPHA-MSH AMIDE (4-10); Ac-Nle(4)-c(asp(5)-2'-nal(7)-lys(10))alpha-msh(4-10)-NH2; Acetyl-norisoleucyl(4)-cyclo(aspartyl(5)-2'-naphthylalanyl(7)-lysyl(10))alpha-msh(4-10)-amide; L-Lysinamide, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, cyclic (2-7)-peptide; N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide cyclic (2-7)-peptide; (3R,6R,9S,12R,15R,23R)-12-((1H-Imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((R)-2-acetamidohexanamido)-6-(3-guanidinopropyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide
- 用途
- 化学合成；作为人类黑皮素受体 3 和 4 (MC3/4R) 拮抗剂，同时是 MC5R 的部分激动剂，对人类 MC3R、MC4R 和 MC5R 的 IC50 值分别为 0.23 nM、0.06 nM 和 0.09 nM；体内研究显示其可增加大鼠食物摄入、体重及脂肪含量，降低能量消耗，影响棕色脂肪组织功能。
