- 英文名称
- PD 145065
- 分子式
- C52H67N7O10
- 分子量
- 950.13
- 中文别名
- 化合物T25923; 化合物PD 145065; PD-145065; PD145065; [AC-DBHG16] ENDOTHELIN-1 (16-21); AC-DBHG-LEU-ASP-ILE-ILE-TRP; AC-D-BHG-LEU-ASP-ILE-ILE-TRP-OH; endothelin receptor antagonist PD 145065; Ac-bhg-Leu-Asp-Ile-Ile-Trp; N-Acetyl-α-[10,11-Dihydro-5H-dibenzo[a,d]cycloheptadien-5-yl]-D-Gly-Leu-Asp-Ile-Ile-Trp; L-Tryptophan, N-[N-[N-[N-[N-[N-acetyl-D-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)glycyl]-L-leucyl]-L-α-aspartyl]-L-isoleucyl]-L-isoleucyl]- (9CI); Ac-(5H-Dibenzyl(a,d)cycloheptene-10,11-dihydroglycine-leu-asp-ile-ile-trp); Acetyl-(5H-dibenzyl(a,d)cycloheptene-10,11-dihydroglycine-leucyl-aspartyl-isoleucyl-isoleucyl-tryptophan); (3S)-3-[[(2S)-2-[[(2R)-2-Acetamido-2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)acetyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid; 2-{1-[1-(2-carboxy-1-{1-[10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl(methylcarboxamido)methylcarboxamido]-3-methylbutylcarboxamido}ethylcarboxamido)-2-methylbutylcarboxamido]-2-methylbutylcarboxamido}-3-(1H-3-indolyl)propanoic acid; (2S,5S,8S,11S,14S,17R)-2-((1H-indol-3-yl)methyl)-5,8-di((S)-sec-butyl)-11-(carboxymethyl)-17-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-14-isobutyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosanoic acid; N-[(2R)-2-Acetamido-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)acetyl]-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan
- 用途
- PD 145065 是一种强效的，非选择性的内皮素受体拮抗剂，对兔肾动脉血管平滑肌细胞的ETA受体 IC50 值为4 nM。
