- 英文名称
- Cyclosporin H
- 分子式
- C62H111N11O12
- 分子量
- 1202.61
- 中文别名
- 环孢素H; 环孢霉素H; 环孢素杂质8; 环孢素H, 来源于小单孢菌; 环[L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酰-N-甲基-L-亮氨酰-N-甲基-L-缬氨酰-3-羟基-N,4-二甲基-L-2-氨基-6-辛烯酰-L-2-氨基丁酰-N-甲基甘氨酰-N-甲基-L-亮氨酰-L-缬氨酰-N-甲基-L-亮氨酰]; 环孢菌素杂质H; (3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-乙基-33-((1R,2R,E)-1-羟基-2-甲基己基-4-烯-1-基)-6,9,18,24-四异丁基-3,21-二异丙基-,4,7,10,12,15,19,25,28-九甲基1,4,7,10,13,16,19,22,25,28,31-十一烷氮杂三十三烷-2,5,8,11,14,17,20,23,26,29,32-十一酮; (3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone; CyclosporinH; cyclosiversioside H; Cyclosporin Impurity 8; 5-(N-Methyl-D-valine)cyclosporin A; Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- 用途
- FPR-1 (甲酰肽受体1) 的选择性强效抑制剂; 病毒转导增强剂，可使人脐带血来源的造血干细胞和祖细胞中慢病毒转导增强10倍; 与雷帕霉素或前列腺素E2联合使用时表现出累加效应; 缺乏环孢素A具有的免疫抑制活性; 可抑制人中性粒细胞中FMLP诱导的超氧阴离子形成; 可抑制HL-60细胞膜中FMLP结合及高亲和力GTP酶激活; 可抑制FMLP对胞质Ca²+浓度、超氧阴离子形成和β-葡萄糖醛酸酶释放的刺激作用; 可减轻LPS或HCl诱导的肺损伤
