- 生物活性
AG-494是EGFR受体自身磷酸化的抑制剂，IC50为1.2 μM。它抑制依赖于EGF的细胞生长，IC50为6 μM。
- 靶点
Target
Value
EGFR
(Cell-free assay)
1.2 μM
- 体外研究
In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis.
AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H
2
O
2
-treated cells.
AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.
