- 英文名称
- Tolinapant
- 分子式
- C30H42FN5O3
- 分子量
- 539.68
- 中文别名
- ASTX660; ASTX-660; AT-IAP; 1-(6-(4-氟苄基)-5-(羟甲基)-3,3-二甲基-2,3-二氢-1H-吡咯并[3,2-b]吡啶-1-基)-2-((2R,5R)-5-甲基-2-(((R)-3-甲基吗啉代)甲基)哌嗪-1-基)乙酮; 1-(6-(4-氟苄基)-5-(羟甲基)-3,3-二甲基-2,3-二氢-1H-吡咯[3,2-B]吡啶-1-基)-2-((2R,5R)-5-甲基-2-((R)-3-甲基吗啉基)甲基)哌嗪-1-基)乙烷-1-酮; ASTX660; ASTX-660; ASTX 660; Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-; 1-(6-(4-Fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethanone; XIAP/cIAP1 Antagonist ASTX660; 1-[6-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methylmorpholin-4-yl]methyl]piperazin-1-yl]ethanone; 1-(6-(4-fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one
- 用途
- Tolinapant (ASTX660)是一种有效的cIAP1/2和XIAP的非拟肽拮抗剂，可抑制SMAC衍生肽分别与XIAP的BIR3域（BIR3-XIAP）和cIAP1的BIR3域（BIR3-cIAP1）之间的相互作用，其IC50值分别小于40 nM和12 nM。
