- 英文名称
- Paxilline
- 分子式
- C27H33NO4
- 分子量
- 435.56
- 中文别名
- 桩菇菌素; 帕克西林; 钙激活钾通道阻断剂; (2R,4bS,6aS,12bS,12cR,14aS)-4b-羟基-2-(2-羟基丙烷-2-基)-12b,12c-二甲基-5,6,6a,7,12,12b,12c,13,14,14a-十氢-2H-苯并吡喃并[5',6':6,7]茚并[1,2-b]吲哚-3(4bH)-酮; PAXILINE; PAXILLINE,PENICILLIUM PAXILLI; Paxicillin; (2R,4bS,6aS,12bS,12cR,14aS)-4b-Hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-4b-Hydroxy-2-(2-hydroxy-2-propanyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one; paxilline from penicillium paxilli; Paxilline 1
- 用途
- BK通道特异的阻断剂，可缓解BK-D434G功能获得所导致的失神癫痫和运动障碍；来自Penicillium paxilli的吲哚生物碱霉菌毒素，通过封闭通道的阻断机制有效抑制BK通道；抑制肌质网Ca2+刺激的ATP酶(SERCA)，对不同亚型SERCA的IC50值为5μM-50μM；具有显著的抗惊厥活性；靶点为SERCA（IC50:5-50μM）、BK通道
