- 英文名称
- 6-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid
- 分子式
- C24H29NO2
- 分子量
- 363.49
- 中文别名
- 6-[1-(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)环丙基]-3-吡啶羧酸; 6-[1-(3,5,5,8,8-五甲基-5,6,7,8-四氢-2-萘基)环丙基]烟酸; 化合物T19703; 化合物LG100268; 6-[1-(5,6,7,8-四氢-3,5,5,8,8-戊甲基-2-萘基)环丙基]-3-吡啶羧酸; 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID; 2-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]pyridine-5-carboxylic acid; 6-[1-(3,5,5,8,8-PentaMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]pyridine-3-carboxylic acid; 3-Pyridinecarboxylicacid,6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)cyclopropyl]-; LG100268; 6-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]pyridine-3-carboxylic acid; LG 100268; AGN 192620; ALRT 268; CD 3127; CD-3127; ALRT-268; LGD 1268; LGD-1268; AGN-192620; LGD 100268; LGD-100268; SC-211737; LG268; LG 268
- 用途
- 化学合成；作为有效的、选择性的、口服活性视黄素X受体（RXR）激动剂，对RXR-α、RXR-β、RXR-γ有高亲和力，用于肺癌研究；体外在RAW264.7细胞中（100 nM-1 μM，24小时）下调CSF3及减少CXCL2、IL-1β mRNA表达；体内在A/J小鼠中（口服饮食，100 mg/kg，每日一次，7周）与卡铂联用显著降低平均肿瘤负荷，减少肺肿瘤生长。
