- 英文名称
- M 1145
- 分子式
- C128H205N37O32
- 分子量
- 2774.23
- 中文别名
- 化合物M1145; RGRGNWTLNSAGYLLGPVLPPPALALA-NH2; 激动剂多肽M 1145; (S)-2-((6S,12S,18S,21S,24S,27S)-21-((1H-Indol-3-yl)methyl)-1,6-diamino-18-(2-amino-2-oxoethyl)-12-(3-guanidinopropyl)-24-((R)-1-hydroxyethyl)-1-imino-27-isobutyl-7,10,13,16,19,22,25-heptaoxo-2,8,11,14,17,20,23,26-octaazaoctacosanamido)-N1-((5S,8S,11S,17S,20S)-1-((S)-2-(((S)-1-(((S)-1-((S)-2-((S)-2-((S)-2-(((2S,5S,8S,11S,14S)-1-amino-5,11-diisobutyl-2,8-dimethyl-1,4,7,10,13-pentaoxo-3,6,9,12-tetraazapentadecan-14-yl)carbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carbonyl)pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-21-hydroxy-11-(4-hydroxybenzyl)-5,8-diisobutyl-17-methyl-1,4,7,10,13,16,19-heptaoxo-3,6,9,12,15,18-hexaazahenicosan-20-yl)succinamide; H-Arg-Gly-Arg-Gly-Asn-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2; L-Alaninamide, L-arginylglycyl-L-arginylglycyl-L-asparaginyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-valyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-
- 用途
- M 1145游离态是一种选择性甘丙肽受体2型(GAL2)激动剂，Ki为6.55 nM，对GAL2亲和力是GAL1的90倍以上、GAL3的76倍以上，对甘丙肽信号转导具有加性效应，体外研究中0.1 μM及以上浓度可产生最大信号转导效应，通过刺激表达GalR2的CHO细胞中肌醇磷酸(IP)生成检测信号转导，EC50为38 nM。
