- 英文名称
- Methyl Arachidonyl Fluorophosphonate
- 分子式
- C21H36FO2P
- 分子量
- 370.48
- 中文别名
- MAFP; 甲基花生四烯酸氟磷酸酯; (all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester; Methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate; Methyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraen-1-ylphosphonofluoridate; Phosphonofluoridic acid, P-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl]-, methyl ester; MAPF; METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER; (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene; Methoxyarachidonoyl Fluorophosphonate; methyl ((5Z,8Z,11Z,14Z)-ICOSA-5,8,11,14-TETRAEN-1-YL)PHOSPHONOFLUORIDATE; methylarachidonyl fluorophosphonate
- 用途
- MAFP is a selective, irreversible inhibitor of cPLA2 and iPLA2; it is also an effective irreversible anandamide amidase inhibitor and a ligand for the CB1 cannabinoid receptor. In vitro, it inhibits iPLA2 with an IC50 of 5 μM in P388D1 cells after 5 min preincubation at 40°C, and shows selectivity for anandamide amidase (3000 and 30000-fold more potent than chymotrypsin and trypsin, respectively), and displaces [3H]CP-55940 binding to CB1 with an IC50 of 20 nM (vs 40 nM for anandamide).
