- 英文名称
- Jervine
- 分子式
- C27H39NO3
- 分子量
- 425.6
- 中文别名
- 白藜芦碱; 杰尔碱; 杰尔文; 介芬碱; 介芬胺; 介藜芦碱; 芥芬鹼; 蒜藜芦碱; 介藜芦胺; 芥芬胺; (2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3-羟基-3',6',10,11b-四甲基-1,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11a,11b-十六氢-3'H-螺[苯并[a]芴-9,2'-呋喃并[3,2-b]吡啶]-11(2H)-酮; (2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3-Hydroxy-3',6',10,11b-tetramethyl-1,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11a,11b-hexadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-11(2H)-one; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-; 17,23-epoxy-3-hydroxy-,(3-beta,23-beta)-veratraman-11-on; 17,23-epoxy-3-hydroxy-,(3beta,23beta)-veratraman-11-on; Iervin; 11-Ketocyclopamine; (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one; 17,23β-Epoxy-3β-hydroxyveratraman-11-one; (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one; (3β,22S,23R)-3-Hydroxy-17,23-epoxyveratraman-11-one; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3-β,23-β)-; (3b,23b)-17,23-Epoxy-3-hydroxyveratraman-11-one; (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one; jerwiny; Jervin-11-one
- 用途
- - 生物活性
Jervine (11-Ketocyclopamine)是Hedgehog信号通路的抑制剂（IC50=500-700 nM），通过与smoothened相互作用抑制shh信号通路。
- 靶点
Target
Value
Hedgehog
Shh
- 体外研究
相较于对照组，暴露于25 μg/ml jervine的软骨细胞在细胞数目上有明显的减少，而在细胞形态或阿尔新蓝染色的强度没有变化。
- 体内研究
暴露于jervine的胚胎会产生颅面骨畸形，与Shh突变胚胎表型类似。这些胚胎的下颌在大小上显著减小，通常会造成门齿的缺失。对受孕小鼠处理以jervine会导致其胚胎发生颌骨缺损，其表型与Prx1。
- 化学性质
白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于藜芦。
